UPS Cargo Plane Crashes Near Louisville Airport, 9 Dead, Many Still Missing

Plane Crashes Near Louisville Airport: UPS cargo plane crash has left at least nine dead and several others injured or unaccounted for, as search and rescue efforts continue in Louisville, Kentucky. The crash occurred on Tuesday evening, November 4, 2025, shortly after UPS Flight 2976 took off from Louisville Muhammad Ali International Airport.

The aircraft, a McDonnell Douglas MD-11, was bound for Honolulu, Hawaii and was carrying more than 38,000 gallons of fuel when it tragically exploded in a massive fireball.

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Search and Rescue Underway After Plane Crashes Near Louisville Airport

As of Wednesday morning, nine fatalities have been confirmed, including the three crew members aboard the flight. Tragically, 16 families have reported loved ones missing, with hopes still high for any potential survivors. At least 15 others have been injured, with two in critical condition and receiving treatment at UofL Health hospitals.

Governor Andy Beshear has declared a state of emergency to expedite relief efforts, with the Kentucky National Guard activated to assist in ongoing operations. “This tragedy has affected so many, and we are doing everything we can to ensure that families have the support they need during this difficult time,” Beshear stated in a press briefing. The search for survivors continues as emergency personnel comb through wreckage and debris.

Explosion and Aftermath of Plane Crash Near Louisville Airport

The explosion that followed the crash left Louisville’s industrial district in ruins. The plane, loaded with enough fuel for its eight-hour flight to Hawaii, exploded almost immediately after it went down. The fire spread quickly to nearby businesses, including Kentucky Petroleum Recycling, a facility that housed tanks of oil and propane, further escalating the danger. Local authorities are urging residents to avoid the crash site, as flammable and potentially explosive materials remain on the ground.

Video footage from security cameras shows the plane struggling to maintain altitude shortly after takeoff. As the plane climbed, flames were seen erupting from its left engine, followed by a catastrophic explosion. The fireball engulfed nearby businesses, including Grade A Auto Parts and Kentucky Truck Parts and Service, leaving massive destruction in its wake. First responders from the Louisville Fire Department battled the blaze for hours, with more than 100 firefighters involved in the operation.

Investigation into the Cause of the Plane Crash

The National Transportation Safety Board (NTSB) is leading the investigation into the cause of the crash, with early reports suggesting that the plane had undergone maintenance in September 2025 and was fully serviced prior to its fatal flight. Surveillance footage has been recovered, showing the plane’s engine catching fire moments before impact, which could provide vital clues in determining the cause.

A piece of the plane’s engine was found intact on the ground, and investigators will closely examine this to understand the circumstances surrounding the crash. While it’s still too early to determine the cause, authorities have indicated that they are focusing on potential mechanical issues, although human error or external factors are also under consideration.

Shelter-in-Place Order and Precautionary Measures

In response to the ongoing danger, a shelter-in-place advisory was issued for those in the area immediately surrounding the crash site. Initially, the zone was extensive, but it has now been reduced to a quarter-mile radius. Authorities have also warned residents to avoid drinking water near the airport as a precaution due to potential contamination.

Louisville International Airport (SDF) has resumed limited operations, though certain taxiways remain closed, and delays are expected as recovery and safety operations continue. Flights are resuming, but travelers are advised to check flight statuses for updates.

Governor Beshear Announces Emergency Fund

Governor Beshear has launched the Team Kentucky Emergency Relief Fund to provide immediate support to victims’ families and assist with recovery efforts. The fund will help ensure that those in need of medical care, shelter, and financial assistance receive the resources they require in the aftermath of this tragedy.

UPS Response and Impact on Operations

UPS, headquartered in Louisville, has suspended operations at its Worldport hub, which is one of the largest cargo facilities in the world. The company has canceled Next Day Air services and grounded flights as it assesses the full scope of the disaster. However, operations resumed on Wednesday, though some delays are expected due to the aftermath of the crash.

A statement from UPS expressed deep sorrow for those impacted by the crash: “Our thoughts and prayers are with the victims, their families, and everyone affected by this devastating event. We are fully cooperating with authorities in their investigation and will provide support to those who need it during this challenging time.”

Family Reunification Efforts

In the wake of the crash, the Louisville Metro Police have set up a Family Reunification Area for those searching for loved ones. Authorities are working to reunite families with missing individuals and provide support to those affected by the tragedy. Debris from the crash has been scattered across the area, and anyone finding pieces of wreckage is asked to report it immediately to local authorities.

What We Know So Far:

• Death Toll: At least 9 fatalities confirmed, including 3 crew members.
• Injuries: 15 injured, with 2 in critical condition.
• Missing Persons: 16 people still unaccounted for.
• Explosion and Fire: A massive fireball engulfed nearby businesses after the plane crashed, spreading flames to facilities with flammable materials.
• Investigation: The NTSB is investigating the cause, with early evidence pointing to a potential engine failure.
• Safety Measures: A quarter-mile shelter-in-place advisory remains in effect. Authorities continue to monitor air and water quality.

As Louisville grapples with the aftermath of this horrific crash, officials and first responders remain focused on recovery efforts, while the community continues to mourn the lives lost in this tragedy. Governor Beshear and other local officials have vowed to provide the necessary resources and support to victims and their families as they navigate the difficult days ahead.